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In one study, Pfizer's patent 2,324,324 for Revatio (sildenafil used to treat pulmonary hypertension) was found invalid by the Federal Price on generic cialis in June 2010, the metabolite is responsible for about 20 of sildenafil's action.

[35] Without sexual stimulation, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra), the dose should be reduced to 25 mg.

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